Background: Differentiating Graves hyperthyroidism from the other causes\nof hyperthyroidism, using serum TRAb testing is essential step for diagnosis.\nObjectives: To study importance of TRAb in the diagnosis of Gravesâ?? disease,\ndistinguishing it from thyroiditis, and comparing it with clinical features and\nother tests such as TPOAb, US thyroid and thyroid scintiscan. Methods: A\ncross-sectional study was conducted on 120 patients attending endocrine clinicErbil\ncity. Patients were studied on clinical feature basis and investigated\nwith serum TRAb, TPOAb, TSH, Free T4, and Ultrasound examination of\nthyroid gland. Fisher exact test and Chi Square test of independence, Correlation\ncoefficient and t-test of independence were used. Results: Fifty-two patients\nwere found to have Gravesâ?? disease; There was significant correlation\nbetween TRAb positivity and diagnosis of Gravesâ?? disease p < 0.05. There was\nalso strong relation between presence of goiter, Orbitopathy and Ultrasound\nfindings and TRAb positivity, p < 0.05. There was statistically significant difference\nbetween mean levels of TRAb and fT4 between Graves patients and\nThyroiditis groups, while there was no statistically significant difference in\nTPOAb and TSH means between the two groups, p > 0.05. Conclusion: A\npositive correlation was found between TRAb titer and positivity and no significant\nrelation between TPOAb levels between Gravesâ?? disease patients compared\nwith thyroiditis patients, respectively.
Loading....